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更新时间:2020-2-27 8:52:39 来源:本站原创 作者:佚名 浏览:

Can a blood pressure drug help ease the painful memory of an ex?

A Montreal researcher says he has found a way to take the emotional sting out a bad breakup by "editing" memories using therapy and a beta blocker.


Dr Alain Brunet has spent over 15 years studying post-traumatic stress disorder (PTSD), working with combat veterans, people who have experienced terror attacks and crime victims.

阿兰·布鲁内博士(Dr Alain Brunet)花了15年时间研究创伤后压力症候群(PTSD),对参加过战争或者经历过恐怖袭击的人,以及罪案受害者等进行研究。

Much of his research has centred on the development of what he calls "reconsolidation therapy", an innovative approach that can help remove emotional pain from a traumatic memory.


At the heart of his work is a humble pharmaceutical - propranolol - a beta blocker long used to treat common physical ailments like hypertension and migraines, but which research now suggests has a wider application.


The reconsolidation method involves taking propranolol about an hour before a therapy session where the patient is asked to write a detailed account of their trauma and then read it aloud.


"Often when you recall memory, if there's something new to learn, this memory will unlock and you can update it, and it will be saved again," the Canadian clinical psychologist tells the BBC.


That process of reconsolidation creates a window of opportunity to target the highly emotional portion of that memory.


"We're using this enhanced understanding on how memories are formed and how they are unlocked and updated and saved again - we're essentially using this recent knowledge coming out of neuroscience to treat patients," says Dr Brunet.


His work has often been compared to the science fiction film Eternal Sunshine of a Spotless Mind, where an estranged couple have their memories of each other erased, though Dr Brunet notes memories aren't gone after reconsolidation therapy, they just stop hurting.

他的工作经常令人联想起那部科幻电影《无痛失恋》(Eternal Sunshine of a Spotless Mind,另译《暖暖内含光》/《王牌冤家》),故事里的一对情侣各自将对彼此的回忆清洗掉。不过布鲁内医生指出,再固化治疗之后的记忆并不会消失,只是不再令人伤心。

Memories, their neutral, factual elements, are saved in the brain's hippocampus. But the emotional tone of the memory is saved in its amygdala.


"Imagine that you are shooting a movie in the old-fashioned way so you have the image and and the sound and they are on two separate channels," he says.


When a person relives their traumatic memory they experience both channels. Propranolol helps target one channel - the emotional aspect of memory - inhibiting its reconsolidation and suppressing its pain.


A memory recalled under the influence of the medication will then be "saved" by the brain in its new, less emotional version.


His research suggests about 70% of patients found relief within a few sessions of reconsolidation therapy.


Dr Brunet has collaborated with other PTSD researchers, including Harvard University's PTSD expert Dr Roger Pitman, in studying the method.

在研究这种疗法时,布鲁内医生与其他PTSD研究人士合作,其中包括哈佛大学的PTSD专家罗杰·皮特曼博士(Dr Roger Pitman)。

More recently, he launched a programme in France in the wake of deadly terror attacks in Paris and Nice, training some 200 doctors in the therapy to help treat victims, witnesses and first responders.


So far, over 400 people have undergone the therapy in that country as part of the programme.


After showing success with post-traumatic stress, the doctor says he wanted to broaden the application for the treatment.


In 2015, along with one of his former graduate students, Michelle Lonergan, at McGill University in Montreal, he turned his attention to the broken hearted and their "romantic betrayals".

2015年,他与自己之前在蒙特利尔麦吉尔大学的一个学生米歇尔·洛纳甘(Michelle Lonergan)一起,将目标转向那些在爱情中受伤和被背叛的人。

"If you look at Greek tragedies what are they of? Essentially betrayals," he says. "It's really at the heart of the human experience."


A bad breakup can also be tremendously painful, he notes, and people can feel emotional reactions similar to those seen in trauma survivors.


The patients they recruited for the study weren't suffering just a mild case of heartbreak. There were cases of infidelity. Some had been suddenly abandoned by someone they believed was a loving partner.


They were struggling to cope and were people who "cannot turn the page, they cannot get over it", says Dr Brunet.


"That's what people were constantly telling them, which is not helpful. But [their friends] are pinpointing the problem."


It was like the patients were "stuck in Groundhog Day" - the 1993 comedy where Bill Murray's character relives the same 2 February day over and over - but were instead stuck obsessively reliving their painful betrayals in their minds.

这些病人就像是《土拨鼠之日》(Groundhog Day,香港译为《偷天情缘》、台湾译《今天暂时停止》)电影中的经历——那是1993年的一部电影,比尔·莫瑞(Bill Murray 又译:标·梅利)饰演的角色一次又一次地重复度过2月2日那一天——这些病人也一样,只不过是终日沉迷在脑中回忆那些令他们痛苦的背叛。

What he and Dr Lonergan found was that, like with PTSD, many of the heartbreak sufferers felt relief, some after a single reconsolidation therapy session.


After five sessions, when they read aloud the memory of their betrayal, they had the "impression that this could have been written by someone else - like reading a novel".


"This treatment approximates the normal working of memory, how we gradually forget and turn the page," he says.


His Montreal-based lab is currently recruiting about 60 people who have suffered infidelity or some other form of deception in a relationship for a new reconsolidation therapy study.


Dr Brunet is also hopeful the scope of reconsolidation therapy can be expanded further, used to treat phobias, addiction, complicated grief.


"Any type of distress which emanates from an emotional event," he says.